Nonpeptide GPIIb/IIIa inhibitors. 10. Centrally constrained alpha-sulfonamides are potent inhibitors of platelet aggregation

Autor:	R. J. Lynch, Rodney A. Bednar, Bohumil Bednar, Jacquelynn J. Cook, L.M. Vassallo, Marie A. Holahan, Stanley L. Gaul, Melissa S. Egbertson, Laura A. Libby, G. R. Sitko, Robert J. Gould, J.J. Lynch, George D. Hartman, Maria T. Stranieri
Rok vydání:	1996
Předmět:	Platelet aggregation Stereochemistry Fibrinogen receptor Aryl Organic Chemistry Clinical Biochemistry Pharmaceutical Science Alpha (ethology) Pharmacology Biochemistry chemistry.chemical_compound GpIIb/IIIa chemistry Drug Discovery Molecular Medicine Potency Platelet Receptor Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 6:2519-2524
ISSN:	0960-894X
DOI:	10.1016/0960-894x(96)00473-8
Popis:	Potency enhancing features of two series of fibrinogen receptor antagonists were combined to give analogs with improved potency and oral activity. Antagonists containing either alkyl or aryl sulfonamides and a central isoindolinone structural constraint demonstrate high affinity for both activated and unactivated platelet receptors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::72ca48d34bf7bd0c8173abb3a1aecb0f https://doi.org/10.1016/0960-894x(96)00473-8 Zobrazit plný text záznamu Full Text from ScienceDirect