Investigation of peak compression effects in packed column supercritical fluid chromatography using chemometrics

Autor:	J. T. Strode, Lars Karlsson, Anders Karlsson, D. Carlsson, Olle Gyllenhaal
Rok vydání:	1997
Předmět:	Packed bed Chemistry Organic Chemistry Clinical Biochemistry Analytical chemistry Compression (physics) Biochemistry Analytical Chemistry Chemometrics chemistry.chemical_compound Temperature and pressure Phase (matter) Carbon dioxide Supercritical fluid chromatography Dihydropyridine derivatives
Zdroj:	Chromatographia. 44:289-294
ISSN:	1612-1112 0009-5893
Popis:	In this paper chemometrics have been used to study and characterize peak compression phenomena in packed column SFC. A carbon dioxide/2-methyl-1-propanol mobile phase was used in the experimental design (modifier concentration, temperature and pressure) and modelling part of the investigation. A cubic interaction term was needed in the model to obtain a reasonable fit, suggesting that all three parameters are of significance in terms of controlling peak compression. At the optimum conditions derived from the model a narrow peak was obtained as predicted.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::72c8d36f59ce5da2e290a67c0fe593ac https://doi.org/10.1007/bf02466397 Zobrazit plný text záznamu Full text from SpringerLink