Biosynthetic Studies on Ant Metabolites of Mellein and 2,4-Dihydroxyacetophenone from {1,2-13C2} Acetate
| Autor: | Chang-Ming Sun, Robert F. Toia |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Pharmacology
Stereochemistry Sodium Organic Chemistry Pharmaceutical Science chemistry.chemical_element Biological activity Metabolism Biology ANT Analytical Chemistry Polyketide chemistry.chemical_compound Complementary and alternative medicine Biochemistry chemistry Biosynthesis Drug Discovery Mellein Molecular Medicine Acetophenone |
| Zdroj: | Journal of Natural Products. 56:953-956 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | The biosynthesis of mellein [3] which occurs in the Australian ponerine ant Rhytioloponera chalybata was studied by feeding the ants with an aqueous solution of sodium [1,2- 13 C 2 ]acetate. During this work, a further component not previously noted in this ant was also isolated and identified as 2,4-dihydroxyacetophenone [4]. Both mellein and acetophenone were examined by 13 C-nmr spectroscopy, and the 13 C- 13 C couplings from the intact acetate units were detected. The results establish that in this ant both mellein and the acetophenone arise via the polyketide pathway |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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