Relation of fibronogen to presence and severity of coronary artery disease is independent of other coexisting heart disease
| Autor: | C. Fechtrup, I. Bolibar, H. Niessner, J. Kienast, Simon G. Thompson, R. Matthias |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Heart disease medicine.diagnostic_test business.industry Disease medicine.disease Fibrinogen Pulmonary hypertension Coronary artery disease Angina Internal medicine Cardiology Medicine Angiocardiography Risk factor Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | American Heart Journal. 125:1601-1605 |
| ISSN: | 0002-8703 |
| Popis: | Six hundred fifty seven patients with angina pectoris underwent coronary angiography after measurement of plasma fibrinogen levels. Coronary artery disease (CAD) was angiographically confirmed in 75% of the patients. Other cardiac disease, either alone or in combination with CAD, was diagnosed in 8% and 11% of cases, respectively; 17% of the patients had no evidence of overt heart disease. Fibrinogen concentrations showed a graded increase according to the severity of coronary stenosis ( p = 0.002) but were not significantly associated with any other cardiac heart disease. However, patients with valvular heart diseases had on average a 5.9% elevation of fibrinogen levels as compared to patients without proven cardiac disease ( p = 0.08), similar to the observed 6.9% increase for CAD ( p = 0.005). On average, patients with cardiomyopathies or pulmonary hypertension had only a 1.6% or 1.2% increase, respectively. The increase in fibrinogen levels associated with CAD was similar in patients with and without coexisting heart diseases. The results demonstrate a significant positive relation of fibrinogen to the presence and severity of CAD irrespective of a possible confounding influence from other cardiac diseases. The results therefore lend support to the hypothesis of a pathogenetic role for fibrinogen as a cardiovascular risk factor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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