| Popis: |
For the purposes of this discussion, the reticuloendothelial or mononuclear phagocyte system will be considered to include monocytes, histiocytes, Kupffer cells, alveolar macrophages, and phagocytic cells in spleen, lymph nodes, bone marrow, the nervous system, and the pleural and peritoneal cavities (Bloom and Fawcett, 1975). Fibroblasts, which are facultative phagocytes, are not usually included in the RES, nor are lymphocytes, but both cell types interact with mononuclear cells in the performance of their functions (Pierce, 1980; Leibovich and Ross, 1975). There are a number of plasma proteins (excluding immunoglobulins) which may play roles in host defense against infection and in wound healing. Some of these are synthesized by, catabolized within, and/or adherent to RES cells, lymphocytes, and fibroblasts. The possible consequences of these protein-cell interactions are the focus of this chapter. |
