METABOLIC STUDIES IN TWO BOYS WITH CLASSICAL PROGERIA

Autor:	Dorothy B. Villee, George Nichols, Nathan B. Talbot
Rok vydání:	1969
Předmět:	Pediatrics Perinatology and Child Health
Zdroj:	Pediatrics. 43:207-216
ISSN:	1098-4275 0031-4005
DOI:	10.1542/peds.43.2.207
Popis:	Two boys with classical progeria have been studied by a variety of laboratories in the Boston area. Evidence for unresponsiveness to growth hormone, relative insulin resistance, and highly cross-linked collagen is presented. The data support the concept that progeria represents a form of mesenchymal dysplasia in which connective tissue cells are unresponsive to growth influences. It is hypothesized that this failure to grow may account for the "older" collagen which may in turn produce structural abnormalities in vessel walls predisposing to atherosclerosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::72bf5dc92a8c7924cee24b3a0a366c06 https://doi.org/10.1542/peds.43.2.207 Zobrazit plný text záznamu