A new triterpene diglycoside from the roots of Bupleurum chinense DC. and its inhibitory effect on adipogensis in 3T3-L1 cells
| Autor: | Yanyan Luo, Yufeng Cao, Xin-Feng Wang, Guolin Zhang, Weicheng Hu, Yujing Feng, Liang Chen, Ashfaq Ahmad Khan, Zhou-Wei Wu, Fu Li, Aftab Yaseen, Bin Chen, Mingkui Wang, Lun Wang, Xueqin Li |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
biology 010405 organic chemistry Chemical structure Organic Chemistry Peroxisome biology.organism_classification 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry Biochemistry Triterpene chemistry Enhancer binding Bupleurum chinense General Pharmacology Toxicology and Pharmaceutics Cytotoxicity Receptor Transcription factor |
| Zdroj: | Medicinal Chemistry Research. 28:239-245 |
| ISSN: | 1554-8120 1054-2523 |
| DOI: | 10.1007/s00044-018-2279-5 |
| Popis: | A new triterpene diglycoside, tibesaikosaponin V (TKV), was isolated from the methanol extract of the roots of Bupleurum chinense DC. by normal and reversed phase column chromatography. The chemical structure of this new compound was elucidated based on extensive spectroscopic analysis, including 1D and 2D NMR, HR-ESI-MS, and chemical degradation method. Our results indicated that TKV inhibited lipid accumulation and triacylglycerol content occurred without cytotoxicity to 3T3-L1 adipocytes. Furthermore, TKV significantly suppressed the mRNA expression of nuclear transcription factors such as, peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα). These results suggest that TKV shows the ability to inhibit 3T3-L1 preadipocyte differentiation of and may have therapeutic potential for obesity and its associated metabolic disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink