PROSTATIC CARCINOMA
| Autor: | Shafiq Ahmad Iqbal, Iftikhar Ahmad, Mumtaz Rasool, Mudassar Saeed Pansota, Shafqat Ali Tabassum |
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| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | The Professional Medical Journal. 22:710-714 |
| ISSN: | 2071-7733 1024-8919 |
| DOI: | 10.29309/tpmj/2015.22.06.1236 |
| Popis: | Introduction: During the past many years the availability of serum PSAas a screening marker, has encouraged its use to diagnose both prostatic cancer and itsrecurrence. Patients with high S/PSA are at increased risk of advanced carcinoma prostate andscreening at an earlier stage would help to manage it accordingly. The aim of this study wasto determine association between serum prostatic specific antigen (PSA) levels and Gleasongrade in prostatic carcinoma patients. Study Design: Descriptive, case series study. Setting:Department of Urology & Renal Transplantation in collaboration with Institutional laboratoryof Bahawal Victoria Hospital, Bahawalpur. Period: June 2012 to June 2014. Materials &Methods: Total 160 patients of age 50-80 years with biopsy proven prostatic carcinoma wereincluded. Patients with h/o radiotherapy for prostatic carcinoma and anti-androgen therapywere excluded. Histological slides of each patient were reviewed by using the Gleason gradingsystem. Gleason grade of each patient was correlated with his serum prostatic specific antigen(PSA) report which was done before surgery or biopsy. Results: In our study, mean age was66.89 ± 9.28 years. Mean serum PSA was 21.41 ± 13.67 ng/ml. Intermediate grade cancerwas found in 38.75% patients followed by moderate to poorly differentiated cancer in 31.86%patients. Gleason score ≥7 was significantly higher in patients with serum PSA >20 ng/mL thanthose with serum PSA ≤ 20 ng/mL (p-value of 0.000). So, serum PSA was positively correlatedwith gleason grade (OR = 3.67, Cl = 95%, P = 0.0001) Conclusion: This study concludedthat there is statistically significant association between serum prostatic specific antigen (PSA)levels and Gleason grade in prostatic carcinoma patients and patients with high prostatespecific antigen are at increased risk of advanced carcinoma prostate. |
| Databáze: | OpenAIRE |
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