The Appearance of a Cutaneous Anaplastic Lymphoma in a Psoriasis Patient Taking Methotrexate
| Autor: | Adam Luber, Rita V. Patel |
|---|---|
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Psoriasis Forum. :20-23 |
| ISSN: | 1557-3168 1089-3504 |
| DOI: | 10.1177/247553030915a00204 |
| Popis: | The use of immunosuppressive therapies, including methotrexate (MTX) in the psoriasis population has been associated with the formation of lymphoproliferative disorders. We present a case of a 78-year-old patient with long-standing psoriasis who developed an anaplastic cutaneous lymphoma after approximately 16 months of treatment with 15 mg per week of MTX. Within a month of diagnosis, the MTX was tapered and acitretin was started. Ten weeks later, the patient's lymphoma was clinically resolved, and his psoriasis was well controlled with acitretin and topical therapy as needed. Until further investigation in the form of large prospective clinical trials are completed to substantiate the carcinogenic risk of this antipsoriatic therapy, physicians should be made aware of this plausible association and, along with regular blood work for hepatotoxicity, careful skin screening should be conducted regularly. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|