The Synthesis of Bromomethyltrifluoroborates through Continuous Flow Chemistry

Autor:	Robert B. Perni, Karl W. Ace, Bruce G. Szczepankiewicz, Ben Hagger, Simon A. Watson, Malcolm B. Berry, Gary Lacking, Ranjit Chima, Toby Broom, Gareth Alford, Andrew Rutter, Paul Evans, Christopher Cunningham, Graeme Marchbank, Mark J. Hughes, John C. Roberts
Rok vydání:	2013
Předmět:	Chemical engineering Chemistry Continuous flow Scientific method Potassium Reagent Organic Chemistry chemistry.chemical_element Fraction (chemistry) Physical and Theoretical Chemistry
Zdroj:	Organic Process Research & Development. 18:1354-1359
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op400090a
Popis:	A continuous flow process was developed for the synthesis of potassium bromomethyltrifluoroborate, a key precursor for Suzuki–Miyaura coupling reagents. The continuous flow process was used to produce potassium bromomethyltrifluoroborate on scales from grams to kilograms, and the successful process utilized a fraction of the resources required for the batch synthesis. In the plant, a team of three people produced approximately 100 kg of potassium bromomethyltrifluoroborate in less than 4 weeks. This process makes it both practical and economical to use potassium bromomethyltrifluoroborate and its derivatives for multikilogram-scale Suzuki–Miyaura couplings.
Databáze:	OpenAIRE
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