Optical Coherence Tomography Structural Abnormality Detection in Glaucoma Using Topographically Correspondent Rim and Retinal Nerve Fiber Layer Criteria
| Autor: | Balwantray C. Chauhan, Haomin Luo, Glen P. Sharpe, Christy Hardin, Brad Fortune, Jin Wook Jeoung, Marcelo T. Nicolela, Jayme R Vianna, Claude F. Burgoyne, Steven L. Mansberger, Ya Xing Wang, Hongli Yang, Cindy Albert, Juan Reynaud, Stuart K. Gardiner, Shaban Demirel |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
genetic structures Nerve fiber layer Glaucoma 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Optical coherence tomography Ophthalmology medicine 030304 developmental biology Abnormality detection 0303 health sciences medicine.diagnostic_test business.industry Retinal medicine.disease eye diseases medicine.anatomical_structure chemistry 030221 ophthalmology & optometry Optic nerve sense organs Tomography Abnormality business |
| Zdroj: | American Journal of Ophthalmology. 213:203-216 |
| ISSN: | 0002-9394 |
| Popis: | Purpose This study evaluated the ability of topographically correspondent (TC) minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (pRNFLT) criteria to detect optical coherence tomography (OCT) structural abnormality in glaucoma (GL) and glaucoma suspect (GLS) eyes. Design Retrospective cross-sectional study. Methods A total of 196 GL eyes, 150 GLS eyes, and 303 heathy eyes underwent pRNFL and 24 radial optic nerve head OCT imaging and manual correction of the internal limiting membrane, Bruch's membrane opening (BMO), and outer pRNFL segmentations. MRW and pRNFLT were quantified in 6 Garway-Heath or 12 30-degree (clock-hour) sectors. OCT abnormality for each parameter was defined to be less than the 5th percentile of the healthy eye distribution. OCT abnormality for individual eyes was defined using global, sectoral, and combined parameter criteria that achieved ≥95% specificity in the healthy eyes. TC combination criteria required the sectoral location of MRW and pRNFLT abnormality to be topographically aligned and included comMR (a previously reported TC combination consisting of MRW and pRNFLT parameter: [MRW + pRNFLT × (average MRW healthy eyes/average pRNFLT healthy eyes) MRW]. Results TC sectoral criteria (1 Garway-Heath MRW + corresponding Garway-Heath RNFLT), (one 30-degree MRW + any 1 corresponding or adjacent 30-degree pRNFLT), 30-degree and Garway-Heath comMR-TI and global comMR were the best performing criteria, demonstrating (96%-99% specificity), 86%-91% sensitivity for GL, 80%-84% sensitivity for early GL (MD ≥ −4.0 dB) and 93%-96% sensitivity for moderate-to-advanced GL (MD Conclusions Clinically intuitive TC MRW and pRNFLT combination criteria identified the sectoral location of OCT abnormality in GL eyes with high diagnostic precision. |
| Databáze: | OpenAIRE |
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