An original one-pot synthesis of 5-(4-pyridyl)-benzo[c]-2,7-naphthyridine as key intermediate in the synthesis of amphimedine by metalation connected with cross-coupling reaction

Autor:	F. Guillier, F. Nivoliers, Guy Quéguiner, Francis Marsais, Alain Godard
Rok vydání:	1994
Předmět:	Chemical coupling Stereochemistry Chemistry Metalation One pot reaction Organic Chemistry Drug Discovery Halogen One-pot synthesis Amphimedine Biochemistry Directed ortho metalation Coupling reaction
Zdroj:	Tetrahedron Letters. 35:6489-6492
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)78253-0
Popis:	A short new route to 4,5-disubstituted-benzo[c]-2,7-naphthyridines has been developed. The strategy involves directed ortho metalation of pyridines following by an halogen dance reaction and biaryl cross-coupling as key steps. A concise and efficient one-pot synthesis of 4-chloro-5-(4-pyridyl)-benzo[c]-2,7-naphthyridine, as a key intermediate in the synthesis of amphimedine is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::72a04672cc6ec3626fab91648d32e886 https://doi.org/10.1016/s0040-4039(00)78253-0 Zobrazit plný text záznamu