Syntheses of nucleosides with a 1′,2′-β-lactam moiety as potential inhibitors of hepatitis C virus NS5B polymerase

Autor:	Ruijun Sun, David B. Olsen, Peter T. Meinke, Yunfeng Bai, Zhibo Zhang, Stephane L. Bogen, Vinay Girijavallabhan, Tongqian Chen, Jie Yin, Qun Dang
Rok vydání:	2014
Předmět:	Purine Stereochemistry Hepatitis C virus Organic Chemistry Prodrug medicine.disease_cause Biochemistry Ns5b polymerase chemistry.chemical_compound chemistry Yield (chemistry) Drug Discovery Lactam medicine Moiety Nucleoside
Zdroj:	Tetrahedron Letters. 55:5576-5579
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2014.08.072
Popis:	To discover novel nucleosides as potential anti-HCV agents, nucleosides with a 1′,2′-β-lactam moiety were designed as a hybrid scaffold of MK-608 and GS-6620. Synthetic strategies were successfully developed to prepare two series of C-nucleosides with a 1′,2′-β-lactam moiety: a 7-deaza-purine C-nucleoside analog 11 was prepared in 10 steps with an overall yield of 3.7%; a purine C-nucleoside analog 22 was prepared in 9 steps with an overall yield of 9.7%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::729ad0fb26be132e167b094c1e4af45d https://doi.org/10.1016/j.tetlet.2014.08.072 Zobrazit plný text záznamu Full Text from ScienceDirect