Peripheral and Central Nervous System Effects of Nabam and Ethylenethiourea in Rats
| Autor: | P. Kurttio, K. Savolainen, H. Komulainen, H. Hervonen |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Aché Central nervous system 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine 030304 developmental biology Benzodiazepine receptor binding Cholinesterase Ethylenethiourea 0303 health sciences biology Chemistry Acetylcholinesterase language.human_language 3. Good health medicine.anatomical_structure Endocrinology language biology.protein Cholinergic Acetylcholine medicine.drug |
| Zdroj: | Archives of Toxicology ISBN: 9783540165897 |
| Popis: | Thiurams and dithiocarbamates are neurotoxic and may lead to peripheral motor neuropathy as well as morphological alterations in the central nervous system (CNS) (Sterman and Schaumburg 1980) and in the cholinergic nerves in the gut of rat (Savolainen et al. 1984; Savolainen and Hervonen 1985). Wistar male rats received 0–200 mg/l of nabam and 0–300 mg/1 of ethylenethiourea (ETU), a metabolite of nabam, in drinking water for 28 d. The daily doses for nabam were 8.4–30.5 and for ETU 10.6–34.4 mg/kg. Isolated ilea of all rats showed similar responses to acetylcholine. Nabam decreased the responses of ilea to 5-hydroxytryptamine, whereas the responses were slightly increased by ETU. Both agents tended to increase the responses of the ilea to nicotine. Nabam increased the histochemical reactivity of acetylcholinesterase (AChE) and non-specific cholinesterase of the ilea, whereas ETU had only a marginally decreasing effect on AChE. ETU had no apparent effect on specific 3H-flunitrazepam binding in the rat brain. The present data suggest that cholinergic peripheral nerves rather than the central nervous system (Komulainen and Savolainen, 1985) are targets of neurotoxic effects of dithiocarbamates or their metabolites. |
| Databáze: | OpenAIRE |
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