Palladium-catalysed cross-coupling as a key step in the synthesis of pyridyl-benzamides, -benzylamines and -sulfonamides

Autor:	Charles R. K. Changunda, Sandy van Vuuren, Moira L. Bode, Adriaan E. Basson, Amanda L. Rousseau
Rok vydání:	2017
Předmět:	010405 organic chemistry Chemistry Ligand Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Nucleophilic aromatic substitution Drug Discovery Fluorine Organic chemistry Palladium
Zdroj:	Tetrahedron. 73:137-147
ISSN:	0040-4020
Popis:	Novel N-, O- and S-substituted pyridyl-benzamides, -benzylamines and -sulfonamides were prepared by means of palladium-catalysed cross-coupling reactions. The synthetic approach, using Pd2(dba)3 as palladium source and rac-BINAP as supporting ligand, proved to be successful for C N, C O and C S cross-coupling reactions. One of the substrates underwent an unexpected nucleophilic aromatic substitution of fluorine, rather than the expected C N cross-coupling reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::727d4993f7790e89ca555aa4ce5af8f8 https://doi.org/10.1016/j.tet.2016.11.071 Zobrazit plný text záznamu Full Text from ScienceDirect