Synthesis of Collagen-Like Sequential Polypeptides Containing O -Phospho-L -Hydroxyproline and Preparation of Electrospun Composite Fibers for Possible Dental Application

Autor:	Shigenari Kimoto, Kousaku Ohkawa, Mina Yamaguchi, Naoto Kameyama, Hisaaki Shinji, Shigeaki Kurata, Shinya Hayashi, Hiroyuki Yamamoto
Rok vydání:	2008
Předmět:	food.ingredient Polymers and Plastics Chemistry Chemical structure Sealant Composite number chemistry.chemical_element Bioengineering Calcium Gelatin Electrospinning Biomaterials Extracellular matrix food Biochemistry Materials Chemistry Biotechnology Nuclear chemistry Biomineralization
Zdroj:	Macromolecular Bioscience. 9:79-92
ISSN:	1616-5187
Popis:	A synthetic route is described for collagen-like polypeptides constructed from O-phospho-L-hydroxyproline [Hyp(PO(3)H(2))] residues. Using the synthetic polypeptides and a natural protein, gelatin, fine fibers and their network structures (ESNWs) were prepared via electrospinning. The composite ESNWs can induce the mineralization of calcium phosphate. The phosphoryl groups of the Hyp(PO(3)H(2)) residues affect both the crystalline phase and amount of the calcium phosphate, depending on the chemical structure in the repeating sequence. The composite ESNWs can be developed as a biocompatible replacement of the extracellular matrix of hard tissues, and thus can be applied as dental materials for restoration of dental cavities or as a sealant for pits and fissures.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::727b3540785dc3387a289f77ec0e673f https://doi.org/10.1002/mabi.200800122 Zobrazit plný text záznamu Plný text