| Autor: |
Aoran Yang, Xinhuan Wang, Chao Shang, Yaofeng Hu, Chen Pan, Yang Hong |
| Rok vydání: |
2021 |
| DOI: |
10.21203/rs.3.rs-1142715/v1 |
| Popis: |
Background Most studies related to N6-methyladenosine (m6A) in glioma have been conducted only at the single-gene level, while the m6A modification patterns and correlation between m6A and immune cells’ tumor microenvironment infiltration have not been comprehensively reported. Methods Eighty-five clinical samples were obtained from the Gene Expression Omnibus; another 599 clinical samples and 174 transcriptome data were obtained from The Cancer Genome Atlas. Based on data analysis using the R program and principal component analysis, we established an m6Ascore quantitative scoring system and analyzed the modification of 22 m6A-related genes with TME infiltration characteristics. Results Three m6A modification patterns and the characteristics of immune cell infiltration were identified. Cluster A corresponded to the immune-desert phenotype, cluster B corresponded to the immune-excluded phenotype, and cluster C corresponded to the immune-inflamed phenotype. Cluster B showed the worst long-term prognosis, whereas cluster A had the best long-term prognosis. Anti-CD52/HE5 shows potential as an immune therapy for glioma. Conclusions This research provides a foundation for understanding m6A modification patterns in glioma and a potential prognostic biomarker and immune therapy target for treat glioma. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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