Cryopreserved Placental Explants Increase Lifespan of Male Mice and Change Survival Features of Female Mice
Autor: | Vladimir Yu. Prokopyuk, O. S. Prokopyuk, Victoria V. Lazurenko, I. B. Musatova, Oleg V. Chub, Oksana V. Falko, N. A. Shevchenko, Aleksandra N. Tischenko |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
education.field_of_study Population Autophagy Biophysics Medicine (miscellaneous) Cell cycle Biology Cryopreservation Andrology 03 medical and health sciences 030104 developmental biology Immune system medicine.anatomical_structure Placenta medicine education Survival rate Survival analysis |
Zdroj: | Problems of Cryobiology and Cryomedicine. 27:143-150 |
ISSN: | 2518-7376 2307-6143 |
Popis: | According to the WHO data, to date the population lifespan is increasing worldwide due to infant mortality decrease, rather than the duration and life quality of elderly people. Most effective geroprotectors affect the immune and nervous systems, cellcycle, metabolism of carbohydrates, stimulate autophagy. Bioobjects of placental origin possess similar properties. The research aim was to study the effect of cryopreserved human placental explants on lifespan of BALB/c mice. Kaplan-Meier survival curves were analyzed and survival indices were calculated. The differences were determined using the Log-rank test. It has been shown that implantation of cryopreserved placental explants to experimental animals significantly increases the indices in male mice as follows: median of lifespan - by 17.6%; average life expectancy – by 18.1%; 90% survival rate – by 20.8%; maximum lifespan – by 17.9%. The administration of placental explants to female mice did not affect their lifespan, but reduced the probability of death in the reproductive period.Probl Cryobiol Cryomed 2017; 27(2): 143–150 |
Databáze: | OpenAIRE |
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