Opportunistic infections: Treatment and developmental therapeutics of cryptosporidiosis and isosporiasis

Autor:	Vassil St. Georgiev
Rok vydání:	1993
Předmět:	biology medicine.drug_class Spiramycin Antibiotics Isosporiasis Cryptosporidium biology.organism_classification medicine.disease Azithromycin Trimethoprim Virology Isospora Maintenance therapy parasitic diseases Drug Discovery Immunology medicine medicine.drug
Zdroj:	Drug Development Research. 28:445-459
ISSN:	1098-2299 0272-4391
Popis:	Cryptosporidium sp. and Isospora sp. are coccidian protozoans taxonomically related to Toxoplasma gondii and Plasmodium sp. Although associated with many animal species, these pathogens are also the causative agents of cryptosporidiosis and isosporiasis, 2 invasive opportunistic infections in humans. In immunocompetent hosts, the infections are usually self-limited, flu-like gastrointestinal disorders which resolve spontaneously. In immunocompromised patients, however, cryptosporidiosis is a severe, debilitating, and prolonged illness, with high morbidity and no known therapy effective against it. Spiramycin has been proven largely ineffective. In recent years, however, the use of immunotherapy is being actively pursued as one potentially useful approach for the treatment of cryptosoporidiosis. Azithromycin, a new macrolide antibiotic, has also shown promise in preclinical studies. In the case of isosporiasis, the combination of trimethoprim and sulphamethoxazole has been found to be effective, although AIDS patients have shown a high rate of relapse and, therefore, the need for suppressive maintenance therapy. © Wiley-Liss, Inc.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::725d403b77adf28b2171cd0818ff9836 https://doi.org/10.1002/ddr.430280402 Zobrazit plný text záznamu Plný text