Signalling through the leukotriene B4 receptor involves both αi and α16, but not αq or α11 G-protein subunits

Autor:	S Métaoui, C. Le Gouill, Marek Rola-Pleszczynski, Rémi Gaudreau, S Lemire, Jana Stankova
Rok vydání:	1998
Předmět:	Leukotriene animal structures Phospholipase C G protein viruses fungi Leukotriene B4 receptor Endogeny Cell Biology Transfection Biology Biochemistry Cell biology chemistry.chemical_compound chemistry embryonic structures Inositol Receptor Molecular Biology
Zdroj:	Biochemical Journal. 335:15-18
ISSN:	1470-8728 0264-6021
DOI:	10.1042/bj3350015
Popis:	COS-7 cells transfected with the leukotriene (LT) B4 receptor (BLTR) cDNA were unable to produce LTB4-induced inositol phosphates (IPs) in spite of the presence of endogenous Galphai, Galphaq and Galpha11 proteins. Co-transfection of BLTR with Galpha16, however, resulted in high levels of IP production, which were 17-, 10- and 6-fold higher than with co-transfected Galpha11, Galphaq and Galpha14, respectively. Co-transfection of BLTR with phospholipase C (PLC) beta2, on the other hand, resulted in efficient IP production and co-transfection of BLTR with both Galpha16 and PLCbeta2 resulted in a greater than additive response.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::725844328a56165e807913dadf13d582 https://doi.org/10.1042/bj3350015 Zobrazit plný text záznamu