Major Histocompatibility Complex gene Polymorphism in Systemic Lupus Erythematosus Patients
| Autor: | Methak J. Al-Jboori, Mona N. Al-Terehi, Zahraa Haleem Alqaim |
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| Rok vydání: | 2020 |
| Předmět: |
Genetics
Systemic lupus erythematosus biology Health Toxicology and Mutagenesis Haplotype Single-strand conformation polymorphism Toxicology Major histocompatibility complex medicine.disease Pathology and Forensic Medicine genomic DNA Polymorphism (computer science) MHC class I biology.protein medicine Law Gene |
| Zdroj: | Indian Journal of Forensic Medicine & Toxicology. |
| ISSN: | 0973-9130 0973-9122 |
| DOI: | 10.37506/ijfmt.v14i4.11783 |
| Popis: | The major histocompatibility complex (MIC) is one of the MHC class I related genes which related withautoimmune diseases , the present study aims to investigated association between MIC gene polymorphismclass I in systematic lupus erythrymatous patients within Hilla city, the present study implemented usingwhole blood genomic DNA and single strand DNA conformation polymorphism (SSCP) for detection genepolymorphisms and haplotypes frequency, The results of present study show that 183 bp of MIC gene and ithas three haplotypes (A, B, and C) each of these haplotypes consist of two bands, non-significant differencesbetween patient and control in haplotypes frequency, B haplotype was more frequent in patinas than others(20%) while A was more frequents in control than others (22.8%). The present study concluded that MICgene may be contributed in immune response of SLE and can be used in pre diagnosis of disease. This studywas one of the serious investigators deal with several immune genes in this disease in Iraqi SLE. |
| Databáze: | OpenAIRE |
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