Development of a bioactive implant for repair and potential healing of cranial defects

Autor:	Lars Kihlström, Håkan Engqvist, Ann-Charlott Docherty Skogh, T. Kalle Lundgren, Hans Jacobsson, Thomas Engstrand, Jan Bohlin, Erik Neovius, Jonas Åberg
Rok vydání:	2014
Předmět:	medicine.medical_specialty Craniofacial bone business.industry Regeneration (biology) Dentistry Soft tissue Bone healing Surgery Cranial vault medicine Implant business Wound healing Cranial implant
Zdroj:	Journal of Neurosurgery. 120:273-277
ISSN:	1933-0693 0022-3085
DOI:	10.3171/2013.6.jns1360
Popis:	The repair of complex craniofacial bone defects is challenging and a successful result is dependent on the size of the defect, quality of the soft tissue covering the defect, and choice of reconstruction method. The objective of this study was to develop a bioactive cranial implant that could provide a permanent reconstructive solution to the patient by stimulating bone healing of the defect. In this paper the authors report on the feasibility and clinical results of using such a newly developed device for the repair of a large traumatic and therapy-resistant cranial bone defect. The patient had undergone numerous attempts at repair, in which established methods had been tried without success. A mosaic-designed device was manufactured and implanted, comprising interconnected ceramic tiles with a defined calcium phosphate composition. The clinical outcome 30 months after surgery revealed a restored cranial vault without postoperative complications. Computed tomography demonstrated signs of bone ingrowth. Examination with combined 18F-fluoride PET and CT provided further evidence of bone healing of the cranial defect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7251bc0bbd2f287728b4e2eb200cc733 https://doi.org/10.3171/2013.6.jns1360 Zobrazit plný text záznamu