New analogs of pochonicine, a potent β-N-acetylglucosaminidase inhibitor from fungus Pochonia suchlasporia var. suchlasporia TAMA 87
| Autor: | Teruhiko Nitoda, Asami Yamada, Aya Tsuchida, Yuhichi Mushiake, Hiroshi Kanzaki, Toru Okuda |
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| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
biology Pochonia suchlasporia Stereochemistry Health Toxicology and Mutagenesis Hydroxy group Fungus 010501 environmental sciences biology.organism_classification 01 natural sciences Pochonicine 010602 entomology chemistry.chemical_compound chemistry Solid-state fermentation Insect Science N acetylglucosaminidase Fungal strain Fermentation 0105 earth and related environmental sciences |
| Zdroj: | Journal of Pesticide Science. 46:115-119 |
| ISSN: | 1349-0923 1348-589X |
| DOI: | 10.1584/jpestics.d20-086 |
| Popis: | Three novel analogs of pochonicine (1) were isolated from a solid fermentation culture of the fungal strain Pochonia suchlasporia var. suchlasporia TAMA 87, and their structures were elucidated as 7-deoxypochonicine (2), 6-deoxypochonicine (3), and 6,7-dideoxypochonicine (4). These analogs were found to possess the same stereochemistry as pochonicine. Comparison of β-N-acetylglucosaminidase (GlcNAcase) inhibitory activity between these analogs and pochonicine suggested that the C-6 hydroxy group of pochonicine was essential to its potent GlcNAcase inhibitory activity and that the C-7 hydroxy group also contributed to the activity, but to a lesser extent than the C-6 hydroxy group. |
| Databáze: | OpenAIRE |
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