Antitumor Activity and Toxicity of Olivamide Dosage Form, a New Semi-Synthetic Olivomycin a Derivative

Autor:	I. D. Treshchalin, Anna N. Tevyashova, M. I. Treshchalin, E. R. Pereverzeva
Rok vydání:	2019
Předmět:	Pharmacology Antitumor activity Chemistry medicine.drug_class Antibiotics Olivomycin A Dosage form chemistry.chemical_compound Drug Discovery Toxicity medicine Syngenic Chronic toxicity Derivative (chemistry)
Zdroj:	Pharmaceutical Chemistry Journal. 52:902-906
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-019-01923-2
Popis:	Methods for selective chemical modification of the antibiotic olivomycin A (OA) were developed at G. F. Gause Institute of New Antibiotics. The compound with the highest activity against various tumor cell lines was selected from a series of OA analogs. The aim of the work was to study the antitumor activity and toxicity of a dosage form of this compound, i.e., olivamide. Antitumor activity was studied in four syngenic grafted murine tumors. Chronic toxicity was assessed in experiments with rats that determined the animal body mass, clinical and biochemical blood analysis, urinalysis, electrocardiography, and structures of internal organs. The preparation exhibited high antitumor activity and displayed dose-dependent nephro- and hepatotoxic properties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::723ece91b03072fe7d7b196aae1cfecd https://doi.org/10.1007/s11094-019-01923-2 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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