| Autor: |
M Ortega, M Eguren, B Ferrer, Ma Teus, L De Benito-Llopis |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Acta Ophthalmologica Scandinavica. 85 |
| ISSN: |
1395-3907 |
| DOI: |
10.1111/j.1600-0420.2007.01062_3267.x |
| Popis: |
Purpose: To study the effects of mitomycin C (MMC) on the corneal regrowth after laser-assisted subepithelial keratectomy (LASEK). Methods: We performed a prospective, observer-masked study of 64 consecutive eyes (64 patients) scheduled to undergo LASEK to correct myopia. The patients were divided into two age-matched groups. 32 eyes in which the ablation depth was ≤50 μm were included in group 1 and received no MMC. 32 eyes in which the ablation depth exceeded 50 μm were included in group 2 and were treated with intraoperative MMC 0.02% for 30 seconds over the ablated zone. A masked observer measured the corneal thickness 1 and 3 months postoperatively. We compared the increase in central corneal thickness (CCT) during the postoperative period between both groups, assuming that that increment would correspond mainly to the epithelial hyperplasia that occurs after surface ablation. Results: The mean patient age was 31.5±4.6 years and 31.6±8.7 years in groups 1 and 2, respectively (P=0.9). Group 1 showed a mean CCT of 444.0±41.3 μm one month after surgery and 450.3±43.5 μm three months after surgery (P=0.04). CCT in group 2 was 399.7±31.2 μm one month and 407.9±32.6 μm three months after surgery (P=0.006). The difference between the CCT increments between both groups was not statistically significant (P=0.6). Conclusions: A single intraoperative application of MMC 0.02% during 30 seconds after laser surface ablation did not seem to cause a substantial change in the postoperative corneal thickening after LASEK. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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