Continuous production of patulin by immobilized cells ofPenicillium urticae in a stirred tank reactor

Autor:	Leo A. Behie, Alan Jones, B. H. Lesser, D. Berk, G. M. Gaucher
Rok vydání:	1983
Předmět:	Growth medium Chromatography Continuous stirred-tank reactor Bioengineering General Medicine Biology Applied Microbiology and Biotechnology Continuous production Spore Patulin chemistry.chemical_compound chemistry Botany Bioreactor Yeast extract Mycotoxin Biotechnology
Zdroj:	Biotechnology Letters. 5:785-790
ISSN:	1573-6776 0141-5492
DOI:	10.1007/bf01386648
Popis:	Production of the mycotoxin, patulin, by immobilized cells ofPenicillium urticae was chosen as a model system to study the formation of secondary metabolites on a long term basis. Spores of the fungus were immobilized in carrageenan beads and allowed to germinate in situ by incubation in a growth medium. Production of the antibiotic by the populated biocatalyst was then followed in a continuous stirred tank reactor (CSTR) under three different regimes of nutrient feed. Using a nitrogen free feed, antibiotic production gradually declined but the cells could be re-activated by addition of a diluted growth medium. Prolonged production of patulin (up to 440 h) was observed when a source of nitrogen (ie. yeast extract) was supplied to the feed medium.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::722f514c3d313af81b00d5a514c185f2 https://doi.org/10.1007/bf01386648 Zobrazit plný text záznamu Full text from SpringerLink