Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication
| Autor: | Ole A. Andreassen, Elina J Reponen, Ingrid Dieset, Ingrid Melle, Trude Seselie Jahr Vedal, Kåre I. Birkeland, Erik G. Jönsson, Nils Eiel Steen, Jannicke Fjæra Laskemoen, Linn Rødevand, Espen Molden |
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| Rok vydání: | 2018 |
| Předmět: |
Olanzapine
Psychosis Pediatrics medicine.medical_specialty Risperidone business.industry medicine.medical_treatment medicine.disease 030227 psychiatry 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Schizophrenia Medicine Quetiapine Aripiprazole Thyroid function business Antipsychotic 030217 neurology & neurosurgery Biological Psychiatry medicine.drug |
| Zdroj: | Journal of Psychiatric Research. 106:74-81 |
| ISSN: | 0022-3956 |
| Popis: | Background Disturbances in thyroid function have been associated with use of psychotropic drugs, including antipsychotics. Still, the thyroid function in relation to commonly prescribed antipsychotic drugs and polypharmacy is not fully known. We investigated thyroid function associated with use of antipsychotics in patients with psychotic disorders compared with healthy controls. Methods We included 1345 patients and 989 healthy controls from the Thematically Organized Psychosis (TOP) study, recruiting participants between 18 and 65 years of age in the Oslo-area. All patients underwent a thorough clinical investigation and assessment of medication data. Thyroid function was determined from plasma levels of free thyroxin (fT4) and thyroid-stimulating hormone (TSH). Multiple linear regression analyses were performed to evaluate the association between thyroid parameters and use of antipsychotics, and monotherapy users of olanzapine, quetiapine, aripiprazole or risperidone (N = 473) were investigated separately. Results We found lower levels of fT4 (median 13.70 vs 14.00, p Conclusions Our findings indicate an association between use of antipsychotics and lower fT4. Clinicians should be aware that patients using quetiapine, olanzapine or antipsychotics in psychotropic polypharmacy are especially at risk. |
| Databáze: | OpenAIRE |
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