| Popis: |
The regulation of actin dynamics is central to variety of biological events, including cell motility, chemotaxis, nerve growth cone extension, and establishment of cell polarity. A number of signaling mechanisms control these events and play a role in determining the position and extent of new actin assembly. The understanding of the details is still incomplete, but many of these signals involve receptor stimulation and activation of members of the rho family of small GTPase. One mechanism by which signaling pathways regulate actin polymerization is by controlling the formation of new actin filaments. Activation of the Arp2/3 complex appears to be critical in the nucleation step of this process. In turn, activation of members of the Wiskott-Aldrich protein (WASp) family leads to activation of the Arp2/3 complex. WASp family members appear to play the role of signal integrator, responding to inputs from a variety of extracellular and intracellular signals and converting those signals into effects on actin dynamics. |
