Neocleordane Diterpenoids and Their Artifacts from Teucrium olivarianum
| Autor: | Farouk S. El-Feraly, Mohammed A. Al-Yahya, Ilias Muhammad, Andrew T. McPhail, Humayun H. Mirza |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Pharmacology
chemistry.chemical_classification biology Iridoid medicine.drug_class Stereochemistry Organic Chemistry Teucrium oliverianum Pharmaceutical Science biology.organism_classification Flavones Terpenoid Analytical Chemistry Teucrium chemistry.chemical_compound Complementary and alternative medicine chemistry Drug Discovery medicine Molecular Medicine Diterpene Spectral data Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Journal of Natural Products. 56:830-842 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np50096a005 |
| Popis: | The aerial parts of Teucrium oliverianum yielded five new neocleordane diterpenoids (teucrolins A [4], B [5], C [6], D [7], and E [8]), three neocleordane diterpene artifacts (12-O-methylteucrolivin A [9], 12-O-methylteucrolin A [10], and 12-O-ethylteucrolin A [11]), and the three known diterpenoids teucrolivins A [1], B [2], and C [3]. In addition, four other known compounds were isolated: the sterol 24(S)-stigmasta-5,22,25-trien-3β-ol, the iridoid 8-O-acetylharpagide, and the flavones eupatorin and cirsiliol. The structural assignments of all new diterpenoids and their artifacts were based on 1D and 2D nmr spectral data, chemical derivatization, and X-ray crystallographic analysis of 10; the latter established the relative stereochemistry and the presence of the rare axial substitution at C-3 in 10 and related compounds |
| Databáze: | OpenAIRE |
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