Evaluation of advanced imaging biomarkers at kidney failure in patients with ADPKD: a pilot study

Autor: Stijn Wigerinck, Adriana V Gregory, Byron H Smith, Ioan-Andrei Iliuta, Christian Hanna, Maroun Chedid, Hasan-Daniel N Kaidbay, Sarah R Senum, Shebaz Shukoor, Peter C Harris, Vicente E Torres, Timothy L Kline, Fouad T Chebib
Rok vydání: 2023
Předmět:
Zdroj: Clinical Kidney Journal.
ISSN: 2048-8513
2048-8505
Popis: Background and objectives Autosomal Dominant Polycystic Kidney Disease (ADPKD) presents with variable disease severity and progression. Advanced imaging biomarkers may provide insights into cystic and non-cystic processes leading to kidney failure in different age groups. Methods This pilot study included 39 ADPKD patients with kidney failure, stratified into three age groups (56 years old). Advanced imaging biomarkers were assessed using an automated instance cyst segmentation tool. The biomarkers were compared with an age- and sex-matched ADPKD cohort in early chronic kidney disease (CKD). Results Ht-total parenchymal volume correlated negatively with age at kidney failure. The median Ht-total parenchymal volume was significantly lower in patients older than 56 years. Cystic burden was significantly higher at time of kidney failure and especially in patients who reached it before age 46. The cyst index at kidney failure was comparable across age groups and Mayo Imaging Classes. Advanced imaging biomarkers showed higher correlation with Ht-total kidney volume in early CKD than at kidney failure. Cyst index and parenchymal index were relatively stable over five years prior to kidney failure, whereas Ht-total cyst volume and cyst parenchymal surface area increased significantly. Conclusion Age-related differences in advanced imaging biomarkers suggest variable pathophysiological mechanisms in ADPKD patients with kidney failure. Further studies are needed to validate the utility of these biomarkers in predicting disease progression and guiding treatment strategies.
Databáze: OpenAIRE
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