The relationship of plasma glucagon to the hyperglycaemia and hyperinsulinaemia of surgical operation

Autor:	B. J. Rowlands, A. E. B. Giddings, K. J. O'Connor, R. G. Clark, D. Mangnall
Rok vydání:	1976
Předmět:	Immunoreactive insulin medicine.medical_specialty Arginine business.industry Surgical operation Plasma glucagon Glucagon Fight-or-flight response Endocrinology Basal (medicine) Internal medicine medicine Surgery business Abdominal surgery
Zdroj:	British Journal of Surgery. 63:612-616
ISSN:	1365-2168 0007-1323
DOI:	10.1002/bjs.1800630813
Popis:	In a controlled metabolic study of 42patients undergoing abdominal surgery a significant increase in basal values of immunoreactive glucagon (IRG) was found 24 hours postoperatively. No correlation between the onset and duration of hyperglycaemia and the increase of IRG was observed. No increase in immunoreactive insulin (IRZ) was seen during operation, but there was a rise 24 hours postoperatively. The infusion of arginine was accompanied by a rise in IRG both pre- and postoperatively, but despite the high values obtained there was no accompanying further increase in basal plasma glucose in the postoperative situation. The pre- and postoperative IRI responses were similar. Our evidence suggests that glucagon is not a primary mediator of the stress response, or of the hyperglycaemia of surgical operation in these patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::71f73ce288eafb29c3cf40c63b37e914 https://doi.org/10.1002/bjs.1800630813 Zobrazit plný text záznamu Plný text