SYNTHESIS OF NEW GLYCOPOLYMERS CONTAINING β-D-MANNOPYRANOSE, ANDC-2-SUBSTITUTED β-D-MANNOPYRANOSE RESIDUES AS A NEW CLASS OF INHIBITOR

Autor:	Masugu Kamei, Yasuhiko Nagashima, Yasuhiro Kajihara, Shoji Akai, Ken-ichi Sato, Junko Arai, Masami Bito
Rok vydání:	2001
Předmět:	chemistry.chemical_classification biology Stereochemistry Ligand binding assay Organic Chemistry Radical polymerization Polymer Carbohydrate Biochemistry chemistry.chemical_compound Residue (chemistry) Monomer chemistry Concanavalin A Polymer chemistry Side chain biology.protein
Zdroj:	Journal of Carbohydrate Chemistry. 20:121-143
ISSN:	1532-2327 0732-8303
DOI:	10.1081/car-100103953
Popis:	New styryl monomers containing β-D-mannopyranose, 2-acetamido-2-deoxy-β-D-mannopyranose, 2-deoxy-2-fluoro-β-D-mannopyranose, and 2-deoxy-β-D-arabino-hexopyranose on their side chains, were efficiently synthesized as a new class of a potent inhibitor resistant to exo-α-mannosidase digestion. The binding affinity of the carbohydrate polymers obtained from those mannopyranosyl styryl monomers by radical polymerization with Concanavalin A were evaluated. A binding assay indicated that the multivalency effect and the affinity enhancement attained by modification at the C-2 position of the β-D-mannopyranoside residue resulted in the β-D-mannopyranosyl polymer which has the same affinity as that of the α-D-mannopyranosyl polymer.
Databáze:	OpenAIRE
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