Nickel-catalyzed C-alkylation of thioamide, amides and esters by primary alcohols through a hydrogen autotransfer strategy
| Autor: | Xiuhua Wang, Bo Tang, Jieyu Yue, Li Zhang, Yaxin Sun, Yu Ma, Jianrong Steve Zhou, Kaiyue Fu, Peng Yang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Primary (chemistry) Hydrogen Metals and Alloys chemistry.chemical_element General Chemistry Alkylation Combinatorial chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Nickel chemistry Materials Chemistry Ceramics and Composites Thioamide |
| Zdroj: | Chemical Communications. 56:14083-14086 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | A simple catalyst of Ni(OAc)2 and P(t-Bu)3 enables selective C-alkylation of thioacetamides and primary acetamides with alcohols for the first time. Monoalkylation of thioamides, amides and t-butyl esters occurs in excellent yields (>95%). Mechanistic studies reveal that the reaction proceeds via a hydrogen autotransfer pathway. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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