Nicotine nasal spray with nicotine patch for smoking cessation: randomised trial with six year follow up Commentary: Progress on nicotine replacement therapy for smokers
| Autor: | T. Blondal, L. J. Gudmundsson, I. Olafsdottir, G. Gustavsson, A. Westin, J. Stapleton |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
business.industry
Nicotine patch medicine.medical_treatment media_common.quotation_subject General Engineering General Medicine Abstinence Nicotine replacement therapy Placebo Nicotine Nasal spray Anesthesia medicine General Earth and Planetary Sciences Nicotine nasal spray Smoking cessation business General Environmental Science media_common medicine.drug |
| Zdroj: | BMJ. 318:285-289 |
| ISSN: | 1468-5833 0959-8138 |
| DOI: | 10.1136/bmj.318.7179.285 |
| Popis: | Nicotine nasal spray with nicotine patch for smoking cessation: randomised trial with six year follow up {#article-title-2} Objective : To evaluate the efficacy of using a nicotine patch for 5 months with a nicotine nasal spray for 1 year. Design : Placebo controlled, double blind trial. Setting : Reykjavik health centre. Subjects : 237 smokers aged 22-66 years living in or around Reykjavik. Interventions : Nicotine patch for 5 months with nicotine nasal spray for 1 year (n=118) or nicotine patch with placebo spray (n=119). Treatment with patches included 15 mg of nicotine for 3 months, 10 mg for the fourth month, and 5 mg for the fifth month, whereas nicotine in the nasal spray was available for up to 1 year. Both groups received supportive treatment. Main outcome measure : Sustained abstinence from smoking. Results : The log rank test for 6 years (χ2=8.5, P=0.004) shows a significant association between abstinence from smoking and type of treatment. Sustained abstinence rates for the patch and nasal spray group and patch only group were 51% v 35% after 6 weeks (P=0.011 (χ 2), 95% confidence interval 1.17% to 3.32%), 37% v 25% after 3 months (P=0.045, 1.01% to 3.08%), 31% v 16% after 6 months (P=0.005, 1.27% to 4.50%), 27% v 11% after 12 months (P=0.001, 1.50% to 6.14%), and 16% v 9% after 6 years (P=0.077, 0.93% to 4.72%). Conclusions : Short and long term abstinence rates show that the combination of using a nicotine patch for 5 months with a nicotine nasal spray for 1 year is a more effective method of stopping smoking than using a patch only. The low percentage of participants using the nasal spray at 1 year, and the few relapses during the second year, suggest that it is not cost effective to use a nasal spray for longer than 7 months after stopping a patch. # Commentary: Progress on nicotine replacement therapy for smokers {#article-title-20} |
| Databáze: | OpenAIRE |
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