Risk science in the 21st century: a data-driven framework for incorporating new technologies into chemical safety assessment
| Autor: | Ricky Cheung, Daniel Krewski, Russell S. Thomas, Margit Westphal, Melvin E. Andersen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Physiologically based pharmacokinetic modelling Engineering Quantitative structure–activity relationship Emerging technologies business.industry 010501 environmental sciences Management Science and Operations Research Tiered approach Bioinformatics 01 natural sciences Data-driven 03 medical and health sciences 030104 developmental biology Chemical safety Risk analysis (engineering) Metric (unit) Statistics Probability and Uncertainty Business and International Management Risk assessment business 0105 earth and related environmental sciences |
| Zdroj: | International Journal of Risk Assessment and Management. 20:88 |
| ISSN: | 1741-5241 1466-8297 |
| DOI: | 10.1504/ijram.2017.082560 |
| Popis: | One of the major challenges in chemical safety assessment is prioritisation of the large number of chemicals in commerce. Over the past five years, a new tiered approach to chemical safety assessment that uses margin of exposure (MOE) as the metric for determining the level of testing required, identifies chemicals of greatest concern. This paper evaluates the role of new technologies and novel tools in improving different steps of chemical risk assessment processes such as high throughput screening (HTS) in vitro assay platforms, high content biological omics assays, molecular biomarkers, quantitative structure activity relationship (QSAR) modelling, in vitro to in vivo extrapolation (IVIVE) and physiologically-based pharmacokinetic (PBPK) modelling. Other technologies such as functional genomics, bioinformatics, and computational biology can expedite the analysis. This new approach could potentially be used to prioritise and categorise chemicals on the domestic substance list (DSL) under the Canadian Environmental Protection Act (CEPA). |
| Databáze: | OpenAIRE |
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