ChemInform Abstract: Ni-Catalyzed α-Arylation of Secondary α-Bromo-α-fluoro-β-lactam: Cross-Coupling of a Secondary Fluorine-Containing Electrophile

Autor:	Masaaki Omote, Atsushi Tarui, Yoshihisa Miwa, Akira Ando, Shoji Kondo, Hideki Minami, Kazuyuki Sato
Rok vydání:	2013
Předmět:	Substitution reaction Stereochemistry Aryl Fluorine containing General Medicine Oxazoline biochemical phenomena metabolism and nutrition Medicinal chemistry Catalysis chemistry.chemical_compound chemistry Reagent Electrophile polycyclic compounds Lactam
Zdroj:	ChemInform. 44
ISSN:	0931-7597
DOI:	10.1002/chin.201327085
Popis:	A highly diastereoselective cross-coupling reaction of an α-bromo-α-fluoro-β-lactam with a wide range of aryl Grignard reagents was catalyzed by Ni/bis(oxazoline) in yields of up to 98%. The product was obtained diastereoselectively as an anti-isomer. This is the first successful α-arylation of an α-fluoro-β-lactam to produce diverse α-aryl-α-fluoro-β-lactams.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::71cc4c9ebcf68be3e17d3b2058954655 https://doi.org/10.1002/chin.201327085 Zobrazit plný text záznamu Plný text