| Autor: |
Toshihide Yukawa, Kunisuke Izawa, Yasuhiro Tanaka, Hiroshi Shiragami, Yumiko Uchida, Hisao Iwagami |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
Nucleosides and Nucleotides. 11:391-400 |
| ISSN: |
0732-8311 |
| DOI: |
10.1080/07328319208021713 |
| Popis: |
Regioselective 2′-O-deacetylation of 9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)adenine (1) is achieved by treatment of 1 with β-cyclodextrin (β-CyD) / aq. NaHCO3 or N2H4·H2O / EtOH. The 9-(5-O-Acetyl-3-bromo-3-deoxy-β-D-xylo-furanosyl)adenine (2) obtained is a common intermediate for the synthesis of 2′,3′-dideoxy-adenosine (ddA) (7) and 9-(2-fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-adenine (F-ddA) (9). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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