THU0019 Association of HLA-B*41:02 with Henoch-Schönlein Purpura in Spanish Individuals Irrespective of the HLA-DRB1 Status
| Autor: | Trinitario Pina, A. Navas Parejo, Eva Galíndez-Aguirregoikoa, Vanesa Calvo-Río, Ana Márquez, Begoña Ubilla, Sara Remuzgo-Martínez, J. G. Ocejo-Vinyals, M.Ά. González-Gay, Fernanda Genre, Javier Llorca, Verónica Mijares, Maximiliano Aragües, M. Leόn Luque, Lourdes Ortiz-Fernández, R. Lόpez-Mejías, José A. Miranda-Filloy, F. González Escribano, M. Conde-Jaldόn, J. Martín, Norberto Ortego-Centeno, Santos Castañeda, J. M. Blanco-Madrigal, E. Rubio, Diego de Argila, B. Sevilla Pérez, Roman Blanco |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Henoch-Schonlein purpura business.industry Immunology Odds ratio Human leukocyte antigen medicine.disease Gastroenterology General Biochemistry Genetics and Molecular Biology HLA-B symbols.namesake Rheumatology Internal medicine medicine symbols Immunology and Allergy Population study Allele business HLA-DRB1 Fisher's exact test |
| Zdroj: | Annals of the Rheumatic Diseases. 74:199.2-200 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2015-eular.4915 |
| Popis: | Background To determine whether the human leukocyte antigen ( HLA ) B alleles are implicated in the susceptibility to Henoch-Schonlein purpura (HSP) in the largest series of Caucasian HSP patients ever assessed for genetic studies. Methods The study population was composed of 349 Spanish patients diagnosed with HSP fulfilling the American College of Rheumatology and the Michel et al. classification criteria, and 335 sex and ethnically matched controls. HLA-B phenotypes were determined by sequencing-based typing (SBT) and analyzed by chi-square or Fisher exact test. Results A statistically significant increase of HLA-B*41:02 allele in HSP patients when compared with controls was found (8.3% versus 1.5% respectively; p=0.0001; OR (odds ratio) =5.76 [2.15-19.3]). These results remained statistically significant after adjusting for Bonferroni correction (p=0.0028). An internal validation also confirmed the susceptibility effect on HSP associated with HLA-B*41:02 (OR=5.70 [1.98-16.44]). Since a former study described an association between HLA-DRB1*01:03 and HSP susceptibility, we also evaluated the implication of HLA-B*41:02 independently of HLA-DRB1*01:03 . Interestingly, the association remained statistically significant (p=0.0004, OR=4.97 [1.8-16.9]). No HLA-B association with specific HSP clinical features was found. Conclusions Our study indicates that HLA-B*41:02 is associated with the susceptibility to HSP in Spanish patients irrespective of HLA-DRB1 status. Acknowledgements This study was supported by a grant from “Fondo de Investigaciones Sanitarias” PI12/00193 (Spain). RLM is a recipient of a Sara Borrell postdoctoral fellowship from the Instituto de Salud Carlos III at the Spanish Ministry of Health (Spain) (CD12/00425). FG and BU are supported by funds from the RETICS Program (RIER) (RD12/0009/0013). Disclosure of Interest None declared |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|