Indoloquinones, Part 7. Total Synthesis of the Potent Lipid Peroxidation Inhibitor Carbazoquinocin C by an Intramolecular Palladium-Catalyzed Oxidative Coupling of an Anilino-1,4-benzoquinone
Autor: | Hans-Joachim Knölker, Kethiri R. Reddy, Wolfgang Fröhner |
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Rok vydání: | 2002 |
Předmět: | |
Zdroj: | Synthesis. 2002:557-564 |
ISSN: | 1437-210X 0039-7881 |
Popis: | A highly efficient total synthesis of the potent lipid peroxidation inhibitor carbazoquinocin C is presented. The key-step is a palladium(II)-catalyzed oxidative cyclization of an anilino-1,4-benzoquinone to a carbazole-1,4-quinone which proceeds in up to 91% yield. Using this approach the natural product is obtained in four steps and 39% overall yield starting from aniline. |
Databáze: | OpenAIRE |
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