Indoloquinones, Part 7. Total Synthesis of the Potent Lipid Peroxidation Inhibitor Carbazoquinocin C by an Intramolecular Palladium-Catalyzed Oxidative Coupling of an Anilino-1,4-benzoquinone

Autor:	Hans-Joachim Knölker, Kethiri R. Reddy, Wolfgang Fröhner
Rok vydání:	2002
Předmět:	Natural product Organic Chemistry chemistry.chemical_element Total synthesis Medicinal chemistry Catalysis 1 4-Benzoquinone chemistry.chemical_compound Aniline chemistry Intramolecular force Yield (chemistry) Oxidative coupling of methane Palladium
Zdroj:	Synthesis. 2002:557-564
ISSN:	1437-210X 0039-7881
Popis:	A highly efficient total synthesis of the potent lipid peroxidation inhibitor carbazoquinocin C is presented. The key-step is a palladium(II)-catalyzed oxidative cyclization of an anilino-1,4-benzoquinone to a carbazole-1,4-quinone which proceeds in up to 91% yield. Using this approach the natural product is obtained in four steps and 39% overall yield starting from aniline.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::71c1e8a2f33e8547e83a827b762e3d7d https://doi.org/10.1055/s-2002-20953 Zobrazit plný text záznamu