Pronounced Linear Calcinosis in a Boy with Mild Dermatomyositis
Autor: | María del Carmen Boente, Graciela Nadra, Raul A. Asial, Rudolf Happle |
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Rok vydání: | 2009 |
Předmět: | |
Zdroj: | Dermatology. 219:155-157 |
ISSN: | 1421-9832 1018-8665 |
Popis: | A pronounced linear eruption with ulcerations and calcium extrusion present in a boy with a mild generalized rash clinically consistent with juvenile dermatomyositis or overlap syndrome is reported. Loss of heterozygosity (LOH) is a postzygotic mechanism by which a heterozygous somatic cell may become homozygous or hemizygous at a given gene locus. Such a mechanism can be suspected when a pronounced segmental manifestation of an acquired skin condition with a polygenic background is found to be superimposed on more or less symmetrically distributed nonsegmental lesions of the same disorder. Alternatively, such a segmental manifestation may reflect heterozygosity for a postzygotic mutation involving an additional gene locus. The severe linear lesions in our patient showed a Blaschko-linear arrangement and were superimposed on mild nonsegmental lesions of either amyopathic dermatomyositis or overlap syndrome. Either LOH or a postzygotic mutation at an additional gene locus may explain the pronounced linear involvement. |
Databáze: | OpenAIRE |
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