Impact of gsp mutations in somatotroph pituitary adenomas on growth hormone response to somatostatin analogues: a meta-analysis

Autor:	Alexandra Chrisoulidou, Maria Alevizaki, Alexandra Bargiota, Dimitra Vassiliadi, Lamprini Papanastasiou, Georgios Kanakis, Stylianos K Tigas, Anastasia Theodoropoulou, Stylianos Tsagarakis, Zoe Efstathiadou
Rok vydání:	2015
Předmět:	endocrine system Mutation biology Somatotropic cell Somatic cell Pituitary tumors medicine.disease medicine.disease_cause Somatostatin stomatognathic system Acromegaly medicine GNAS complex locus biology.protein Cancer research Gene
Zdroj:	Endocrine Abstracts.
ISSN:	1479-6848
DOI:	10.1530/endoabs.37.ep728
Popis:	Objective Somatic mutations in the GNAS1 gene, which encodes the alpha-subunit of G stimulatory proteins (gsp), are frequently detected in somatotroph pituitary tumors and have been associated to specific clinical and histopathological characteristics. However, the question whether the presence of a somatic gsp mutation affects the response to somatostatin analog treatment remains unresolved.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::71b01de8dffe2d7d9c2318425b546e62 https://doi.org/10.1530/endoabs.37.ep728 Zobrazit plný text záznamu