Cerebrospinal fluid biomarkers of inflammation in trigeminal neuralgia patients operated with microvascular decompression
| Autor: | Sami Abu Hamdeh, Hans Ericson, Emmanuel Bäckryd, Torsten Gordh, Fredrik Stiger, Kim Kultima, Eva Freyhult, Anders Svenningsson |
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| Rok vydání: | 2019 |
| Předmět: |
Trigeminal nerve
Pathology medicine.medical_specialty business.industry medicine.medical_treatment Microvascular decompression medicine.disease Neurovascular bundle Microvascular Decompression Surgery 03 medical and health sciences 0302 clinical medicine Anesthesiology and Pain Medicine medicine.anatomical_structure Cerebrospinal fluid Neurology 030202 anesthesiology Trigeminal neuralgia medicine Neurology (clinical) Arachnoiditis business 030217 neurology & neurosurgery Blood vessel |
| Zdroj: | Pain. 160:2603-2611 |
| ISSN: | 1872-6623 0304-3959 |
| DOI: | 10.1097/j.pain.0000000000001649 |
| Popis: | Compression of the trigeminal root entry zone by a blood vessel can cause trigeminal neuralgia (TN). However, a neurovascular conflict does not explain all cases of TN, and TN can exist without a neurovascular contact. A common observation during microvascular decompression surgery to treat TN is arachnoiditis in the region of the trigeminal nerve. Thus, aberrant inflammatory mechanisms may be involved in the pathophysiology of TN but information about the role of inflammation in TN is scarce. We used Proximity Extension Assay technology to analyse the levels of 92 protein biomarkers related to inflammation in lumbar cerebrospinal fluid from patients with TN (n = 27) before and after microvascular decompression compared to individuals without TN. We aimed to analyse the pattern of inflammation-related proteins in order to improve our understanding of the pathophysiology of TN. The main finding was that immunological protein levels in the cerebrospinal fluid from patients with TN decreased after surgery towards levels observed in healthy controls. Two proteins seemed to be of specific interest for TN: TRAIL and TNF-β. Thus, inflammatory activity might be one important mechanism in TN. |
| Databáze: | OpenAIRE |
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