Sulfite-Promoted C–H Fluoroalkyl Sulfuration of Imidazoheterocycles with Bromofluoroacetate and Elemental Sulfur

Autor:	Zhao-Sheng Zhang, Zi-Ning Cui, Ri-Yuan Tang, Yong-Chao Gao, Jin-Xin Xie, Zi-Hao Huang
Rok vydání:	2020
Předmět:	010405 organic chemistry Organic Chemistry chemistry.chemical_element One-Step 010402 general chemistry 01 natural sciences Sulfur Catalysis 0104 chemical sciences chemistry.chemical_compound Sulfite chemistry Group (periodic table) Polymer chemistry
Zdroj:	Synthesis. 52:2541-2550
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0040-1707120
Popis:	A transition-metal-free sulfite-promoted three-component C–H sulfuration between imidazoheterocycles, elemental sulfur, and bromofluoroacetate is developed. Sulfites, including Na2S2O4, NaHSO3, and Na2S2O3, are able to promote the formation of two C–S bonds in one step using elemental sulfur as a green sulfurating agent, allowing the rapid introduction of the synthetically useful S-fluoroacetate group into imidazoheterocycles. These new imidazoheterocycle derivatives bearing an S-fluoroacetate group can be easily modified to produce pharmaceutically attractive compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::719ee6dd061735b3052a816582ad6761 https://doi.org/10.1055/s-0040-1707120 Zobrazit plný text záznamu