Chiral Phosphorus Ligands for Enantioselective Enyne Cycloisomerizations
| Autor: | Delphine Brissy, Angela Marinetti |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
Chiral auxiliary Enyne 010405 organic chemistry Enantioselective synthesis Alkyne 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Diphosphines Electrophile Enantiomeric excess |
| Zdroj: | Phosphorus Compounds ISBN: 9789048138166 |
| DOI: | 10.1007/978-90-481-3817-3_10 |
| Popis: | This review intends to highlight the role of phosphorus ligands as chiral auxiliaries in enantioselective enyne cycloisomerizations. A few examples of cycloisomerizations involving polyunsaturated substrates are also discussed. Cycloisomerizations processes are known to follow a variety of reaction pathways according to the nature of the starting materials and the metal used as the catalyst. This implies a specific catalyst design for each class of reactions. Bidentate C2-symmetric diphosphines are the preferred chiral auxiliaries in rhodium and palladium promoted Alder-ene type cyclizations, which are so far the most deeply investigated enantioselective processes. Also, enantioselective variants of cyclizations involving electrophilic activation of the alkyne unit have been reported recently. They have been carried out under Ir, Pt and Au catalysis, by using both bidentate and monodentate chiral phosphines as the ligands. Overall, this literature overview points out the very early stage of development of the field. |
| Databáze: | OpenAIRE |
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