A photoactivable natural product with broad antiviral activity against enveloped viruses including highly pathogenic coronaviruses
| Autor: | Lowiese Desmarets, Yves Rouillé, Karin Séron, Moussa Bamba, Fézan Honora Tra Bi, Simon Bordage, Sevser Sahpaz, Kévin Hervouet, Marion Decossas, Thomas Meunier, Jean Dubuisson, Olivier Lambert, Sandrine Belouzard, Nathan François |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Natural product
Coronavirus disease 2019 (COVID-19) viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus diseases respiratory system Viral membrane medicine.disease_cause Virology respiratory tract diseases chemistry.chemical_compound chemistry Mechanism of action Viral envelope Pheophorbide A parasitic diseases medicine medicine.symptom Coronavirus |
| Popis: | The SARS-CoV-2 outbreak has highlighted the need for broad-spectrum antivirals against coronaviruses (CoVs). Here, pheophorbide a (Pba) was identified as a highly active antiviral molecule against HCoV-229E after bioguided fractionation of plant extracts. The antiviral activity of Pba was subsequently shown for SARS-CoV-2 and MERS-CoV, and its mechanism of action was further assessed, showing that Pba is an inhibitor of coronavirus entry by directly targeting the viral particle. Interestingly, the antiviral activity of Pba depends on light exposure, and Pba was shown to inhibit virus-cell fusion by stiffening the viral membrane as demonstrated by cryo-electron microscopy. Moreover, Pba was shown to be broadly active against several other enveloped viruses, and reduced SARS-CoV-2 and MERS-CoV replication in primary human bronchial epithelial cells. Pba is the first described natural antiviral against SARS-CoV-2 with direct photosensitive virucidal activity that holds potential for COVID-19 therapy or disinfection of SARS-CoV-2 contaminated surfaces. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|