Preliminary investigation of the yeast-mediated reduction of β-keto amides derived from cyclic amines as potential resolution methodology

Autor:	Rachel Saxon, Tomas Hudlicky, Hannes Leisch
Rok vydání:	2008
Předmět:	Inorganic Chemistry chemistry.chemical_compound Resolution (mass spectrometry) chemistry Organic Chemistry Organic chemistry Physical and Theoretical Chemistry Enantiomer Spectral data Catalysis Yeast Diketene Cyclic amines
Zdroj:	Tetrahedron: Asymmetry. 19:672-681
ISSN:	0957-4166
Popis:	2-Methylpiperidine and 2-cyclohexylpiperidine were converted to their respective β-keto amides by treatment with diketene. Several strains of yeast were used to reduce the racemic β-keto amides. The unreacted enantiomers were separated from the β-hydroxy amides, the amides cleaved, and the extent of resolution was determined for the cyclic amines. Detailed experimental and spectral data are provided for all compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::71855eddae60addfec9ef793973a8a4a https://doi.org/10.1016/j.tetasy.2008.02.021 Zobrazit plný text záznamu Full Text from ScienceDirect