Oral Terbinafine and Itraconazole Treatments against Dermatophytes Appear Not to Favor the Establishment of Fusarium spp. in Nail
| Autor: | Olympia Bontems, Florence Baudraz-Rosselet, Julie Verrier, Michel Monod |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Fusarium
medicine.medical_specialty Nail Infection biology Itraconazole food and beverages Dermatology biology.organism_classification Microbiology medicine.anatomical_structure Pharmacotherapy medicine Nail (anatomy) Terbinafine Trichophyton High incidence skin and connective tissue diseases medicine.drug |
| Zdroj: | Dermatology. 228:225-232 |
| ISSN: | 1421-9832 1018-8665 |
| DOI: | 10.1159/000357764 |
| Popis: | Background: Fusarium onychomycoses are weakly responsive or unresponsive to standard onychomycosis treatments with oral terbinafine and itraconazole. Objective: To examine whether the use of terbinafine and itraconazole, which are highly effective in fighting Trichophyton onychomycoses, could be a cause of the high incidence of Fusarium nail infections. Methods: Polymerase chain reaction methods were used to detect both Fusarium spp. and Trichophyton spp. in nails of patients who had either received treatment previously or not. Results: No significant microbiological differences were found between treated and untreated patients. In 24 of 79 cases (30%), Fusarium spp. was detected in samples of patients having had no previous antifungal therapy and when Trichophyton spp. grew in culture. Conclusion: Oral terbinafine and itraconazole treatments do not appear to favor the establishment of Fusarium spp. in onychomycosis. |
| Databáze: | OpenAIRE |
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