Effects of Melatonin and/or Magnesium Supplementation on Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial
| Autor: | Majid Karandish, Mohammad Asghari Jafarabadi, Reihaneh Mousavi, Mohammad Alizadeh, Roshan Nikbakht, Lida Heidari, Hossein Babaahmadi Rezaei |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Antioxidant Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Placebo-controlled study chemistry.chemical_element 010501 environmental sciences Placebo medicine.disease_cause 01 natural sciences Biochemistry Inorganic Chemistry Melatonin 03 medical and health sciences Internal medicine Medicine hirsutism 0105 earth and related environmental sciences 0303 health sciences business.industry Magnesium 030302 biochemistry & molecular biology Biochemistry (medical) General Medicine medicine.disease Polycystic ovary Endocrinology chemistry business Oxidative stress medicine.drug |
| Zdroj: | Biological Trace Element Research. 200:1010-1019 |
| ISSN: | 1559-0720 0163-4984 |
| DOI: | 10.1007/s12011-021-02725-y |
| Popis: | Magnesium and melatonin are known to exert multiple beneficial effects including anti-inflammatory and antioxidant actions. This study was designed to determine the effects of magnesium and/or melatonin supplementation on metabolic profiles in women with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was conducted among 84 subjects with PCOS aged 18-40 years old. Patients were randomly assigned based on the random block procedure to take magnesium, melatonin, magnesium plus melatonin, or placebo for 8 weeks. Fasting blood samples were taken at baseline and after the intervention to quantify related variables. After the 8-week intervention, an insignificant marginal difference was seen in waist circumference (WC) between groups (P = 0.085). Magnesium-melatonin co-supplementation resulted in more reductions in hirsutism compared with other groups (P < 0.001). Serum levels of tumor necrosis factor-α (TNF-α) declined significantly in the melatonin and co-supplementation groups compared to baseline (P < 0.05). Also, magnesium plus melatonin was associated with a more increase in total antioxidant capacity (TAC) levels, as compared to the other treatment groups (P = 0.001). Overall, we found a favorable effect of co-supplementation of magnesium and melatonin for 8 weeks in women with PCOS on hirsutism, serum TNF-α, and TAC levels. Furthermore, melatonin independently contributed to decreased serum values of TNF-α.Clinical trial registration number http://www.irct.ir : IRCT20191130045556N1, January 2020. |
| Databáze: | OpenAIRE |
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