SYNTHESIS AND BIOLOGICALEVALUATION OF NOVEL HETEROCYCLIC DERIVATIVES
| Autor: | Hafidh, Afifa, Chaabane, Hédia, Touati, Fathi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| DOI: | 10.48369/imist.prsm/jmch-v17i2.14122 |
| Popis: | In the current work, novel heterocyclic derivatives containing 1,3,4- thiadiazole ring have been successfully synthesized through nucleophilic addition reaction, by the condensation of 1,3,4-thiadiazole-2,5-diamines (1) as starting material with various electrophilic agents. The newly synthesized compounds were investigated for their antimicrobial activities. Structures of all the prepared compounds have been proved using (FTIR), (1H-NMR) and (13C-NMR) spectra. The synthesized compounds were screened for antibacterial and antifungal activities against Escherichia coli gram(-), Salmonella typhimurium gram(-), Staphylococus aureus gram(+), Enterococcus feaciumgram (+),Streptocoque B(agalactiae)gram (+) and Candida albicans. The synthesized compounds were found to exhibit moderate to high antibacterial and antifungal efficiency against several tested bacterial strains, using agar diffusion method and filter paper disc-diffusion method. Ampicillin was used as positive control for all strains except Candida albicans for which Nystatin was used. The prepared compounds manifested promising biological activity. Moroccan Journal of Heterocyclic Chemistry, Vol 17, No 2 (2018) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|