Comparison of two models of bleomycin-induced lung fibrosis in mouse on the level of leucocytes and T cell subpopulations in bronchoalveolar lavage
| Autor: | Dallas M. Hyde, R. K. Braun, David A. Ferrick, P. J. Kilshaw, A. Sterner-Kock, Shiri N. Giri |
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| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Pathology T cell Integrin Bleomycin Pathology and Forensic Medicine Subcutaneous injection chemistry.chemical_compound Internal medicine Pulmonary fibrosis medicine Hematology medicine.diagnostic_test biology business.industry Lung fibrosis respiratory system medicine.disease respiratory tract diseases Bronchoalveolar lavage medicine.anatomical_structure chemistry Immunology biology.protein Anatomy business |
| Zdroj: | Comparative Haematology International. 6:141-148 |
| ISSN: | 1618-565X 0938-7714 |
| DOI: | 10.1007/bf00368457 |
| Popis: | Bleomycin produces pulmonary fibrosis in mice when given as a single intratracheal instillation or as multiple subcutaneous injections. Both models are associated with a significant deposition of collagen in the lungs but differ in the location of the initial lesions. Intratracheal instillation of bleomycin directs lesions to peribronchial or peribronchiolar sites, whereas subcutaneous injection produces lesions in subpleural and perivascular locations. It was therefore of interest to analyse the bronchoalveolar lavage (BAL) fluid for differences in the cellular composition, especially of intraepithelial T lymphocytes characterised by the expression of the integrin αEβ7. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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